张荣
发布时间：2023-10-10 浏览次数：0次
张荣,博士、博士后、二级教授,博士生导师,河北医科大学科技处副处长,河北省环境与人群健康重点实验室环境毒理学研究方向负责人、河北医科大学医学健康研究院公共卫生与健康管理研究中心副主任、卫生毒理学二级学科负责人,培养了12名博士研究生和20余名硕士研究生,指导9名研究生获得国家奖学金,1名省级三好研究生,8名获得河北省优秀毕业研究生,3篇获得河北省优秀硕士论文,1篇获得河北省优秀博士论文。国家自然科学基金重大研究计划重点项目负责人,河北省优秀教师,兼任中国毒理学会理事,中华预防医学会卫生毒理学分会委员,中华预防医学会环境卫生学分会委员,中国环境诱变剂学会委员,中国毒理学会毒理教育专业委员会常务委员,中国毒理学会工业毒理专业委员会常务委员,中国毒理学会神经毒理专业委员会常务委员,中国毒理学会生化与分子生物学专业委员会委员,中国毒理学会呼吸毒理委员会常委,中国环境诱变剂学会生物标志专业委员会常委等。获得河北省科技进步三等奖2项,主编和参编论著11部,发表研究论文300余篇,其中以第一或通讯作者发表SCI论文57篇,单篇最高影响因子18.962，为毒理学杂志编委,担任PFT、Journal of Hazardous Materials、environmental Pollution、chemosphere等多个杂志的审稿人。
二、研究方向
环境毒理、环境流行病、纳米毒理。
三、承担代表性科研课题
1. 国家自然科学基金重大研究计划重点项目,肺造血免疫介导的室内细颗粒物致心血管系统危害特征的研究（92043202）
2. 国家自然科学基金面上项目,N6-甲基腺苷介导靶向ALKBH2的miRNAs代谢失衡在纳米级炭黑致肺遗传损伤及肿瘤发生发展中的作用（81973074）
3. 国家自然科学基金重大研究计划培育项目,氧化应激因子FOXO在大气细颗粒物致肺遗传损伤中的作用及机制（NO 91643108）
4. 国家自然科学基金面上项目,FOXO信号在纳米级碳黑遗传毒性中的作用及机制研究（NO 81573190）
5. 国家自然科学基金青年基金,FOXO3a-ChK2/XRCC1 在纳米二氧化钛诱导的DNA 损伤修复中的作用研究（NO 81102151）
6. 国家自然科学基金面上项目,基于DNA损伤基因和HCR机制的环境污染物致癌活性快速检测系统的研究（NO 81072269）
7. 中国博士后自然科学基金,《FOXO3a信号在柴油机尾气致DNA损伤中的作用研究》（2013M540124）
8. 河北省自然科学基金精准医学联合基金培育项目, ceRNAs 靶向 NLRP3炎性小体介导的EMT在PM2.5诱导的肺损伤及肿瘤发生展中的作用机,No.H2020206558
9. 河北省自然科学基金面上项目,PLK1/FOXO信号在纳米二氧化钛遗传毒性中的作用,（H2015206326）
10. 河北省自然科学基金面上项目,keap1-Nrf-2/ARE信号通路在纳米二氧化钛诱导氧化损伤中的作用,（NOC2011206048）
四、近三年第一作者/通讯作者发表的代表性论文
1. Zijie Pei, Mengqi Wu, Wenyuan Zhu, Yaxian Pang, Yujie Niu*, Rong Zhang*, Helin Zhang*, Associations of long-term exposure to air pollution with prevalence of pulmonary nodules: A cross-sectional study in Shijiazhuang, China. Ecotoxicology and Environmental Safety 262 (2023) 115311. |
2. Lipeng Li, Tengfei Feng, Ruiting Wu, Yaling Zhang, Ning Wang, Mengqi Wu, Yaxian Pang, Sujuan Yang, Aimin Yang, Dengsuo Zhang, Guimin Hao, Rong Zhang*. The role of total antioxidant capacity and malondialdehyde of seminal plasma in the association between air pollution and sperm quality. Environmental Pollution 335 (2023) 122324. |
3. Lipeng Li, Zijie Pei, Ruiting Wu, Yaling Zhang, Yaxian Pang, Huaifang Hu, Wentao Hu, Zihan Geng, Tengfei Feng, Yujie Niu, Guimin Hao*, Rong Zhang*. FDX1 regulates leydig cell ferroptosis mediates PM2.5-induced testicular dysfunction of mice. Ecotoxicology and Environmental Safety 263 (2023) 115309. |
4. Qingping Liu, Wentao Hu, Yaling Zhang, Jie Ning, Yaxian Pang, Huaifang Hu, Meiyu Chen, Mengqi Wu, Mengruo Wang, Peihao Yang, Lei Bao, Yujie Niu*, Rong Zhang*. Comprehensive Analysis of lncRNA–mRNA Expression Profiles in Depression-like Responses of Mice Related to Polystyrene Nanoparticle Exposure. Toxics 2023, 11, 600. 5. Jie Ning, Zijie Pei, Mengruo Wang, Huaifang Hu, Meiyu Chen, Qingping Liu, Mengqi Wu, Peihao Yang, Zihan Geng, Jie Zheng, Zhe Du, Wentao Hu, Qian Wang, Yaxian Pang, Lei Bao, Yujie Niu, Shuguang Leng, Rong Zhang*. Site-specific Atg13 methylation-mediated autophagy regulates epithelial inflammation in PM2.5-induced pulmonary fibrosis, Journal of Hazardous Materials 457 (2023) 131791. 6. Ding Ji, Chenxi Hu, Jie Ning, Xiaoling Ying, Haiqing Zhang, Bohan Zhang, Bixia Liu, Qingping Liu, Weidong Ji*, Rong Zhang*, N6-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis, Ecotoxicology and Environmental Safety 254 (2023) 114755. 7. Yinsheng Guo, Yue Ma, Weiqiang Zhong, Lixiao Zhou, Yanjian Wan, Huiping Zhu*, Rong Zhang*, Associations between seminal plasma triclosan and low sperm quality: A case-control study. European Journal of Obstetrics and Gynecology 283 (2023) 130-135. 8. Huaifang Hu, Lipeng Li, Huaxing Zhang, Yaling Zhang, Qingping Liu, Meiyu Chen, Jie Ning, Yaxian Pang, Wentao Hu, Yujie Niu*, Rong Zhang*. Mechanism of YY1 mediating autophagy dependent ferroptosis in PM2.5 induced cardiac fibrosis, Chemosphere 315 (2023) 137749. 9. Qingping Liu, Yaling Zhang, Bin Han, Mengruo Wang, Huaifang Hu, Jie Ning, Wentao Hu, Meiyu Chen, Yaxian Pang, Yuanyuan Chen, Lei Bao, Yujie Niu*, Rong Zhang*. circRNAs deregulation in exosomes derived from BEAS-2B cells is associated with vascular stiffness induced by PM2.5. Journal of Environmental Sciences 2023, 2. 10. Wanjun Zhang, Yaxian Pang, Wenting Cheng, Tao Wang, Yanting Li, Xin Li, Jianzhong Zhang, Xiaowen Xia, Yuxin Zheng, Rong Zhang*, Jinglong Tang*, Ex vivo coronary endothelial cell activation associated with indoor coal combustion initiated atherosclerosis, Science of the Total Environment 858 (2023) 160174. 11. Wenting Cheng, Wanjun Zhang, Xiaowen Xia, Jianzhong Zhang, Mingyue Wang, Yanting Li, Xin Li, Yuxin Zheng, Jing Liu, Rong Zhang*, Jinglong Tang*. The domino effect in inhaled carbon black nanoparticles triggers bloode-brain barrier disruption via altering circulatory inflammation, Nano Today 48 (2023) 101721. 12. Chen Chu, Yaling Zhang, Qingping Liu, Yaxian Pang, Yujie Niu*, Rong Zhang*, Identification of ceRNA network to explain the mechanism of cognitive dysfunctions induced by PS NPs in mice, Ecotoxicology and Environmental Safety 241 (2022) 113785. 13. Jie Zheng, Yaxian Pang, Yaling Zhang, Wentao Hu, Peihao Yang, Qingping Liu, Jie Ning, Zhe Du, Xiaoting Jin, Jinglong Tang, Yujie Niu, Yuxin Zheng, Rong Zhang*. Indoor VOCs exposure induced Parkinson-like behaviors through autophagy dysfunction and NLRP3 inflammasome-mediated neuroinflammation. Journal of Hazardous Materials 440 (2022) 129818. 14. Lei Bao, Zihan Geng, Juan Wang, Liyi He, Aijuan Kang, Jianshi Song, Xiaoyan Huang, Yaling Zhang, Qingping Liu, Tao Jiang, Yaxian Pang, Yujie Niu, Rong Zhang*. Attenuated T cell activation and rearrangement of T cell receptor β repertoire in silica nanoparticle-induced pulmonary fibrosis of mice. Environmental Research 213 (2022) 113678. 15. Jie Ning, Hairong Du, Yaling Zhang, Qingping Liu, Tao Jiang, Yaxian Pang, Xiaochen Tian, Liqun Yan, Yujie Niu, Rong Zhang*. N6-methyladenosine modification of CDH1 mRNA promotes PM2.5-induced pulmonary fibrosis via mediating epithelial mesenchymal transition, Toxicological Sciences 185,2 (2022): 143-157. 16. Bin Han, Qingping Liu, Xuan Su, Lixiao Zhou, Boyuan Zhang, Hui Kang, Jie Ning, Chen Li, Bo Zhao, Yujie Niu, Wen Chen, Liping Chen*, Rong Zhang*. The role of PP2A /NLRP3 signaling pathway in ambient particulate matter 2.5 induced lung injury. Chemosphere 2022 Aug 1;307(Pt 2):135794. 8.493. 17. Mengqi Wu, Yaxian Pang, Meiyu Chen, Lipeng Li, Lina Yan, Jie Ning, Qingping Liu, Yaling Zhang, Tao Jiang, Aijuan Kang, Xiaoyan Huang, Wentao Hu, Huaifang Hu, Zihan Geng, Liyi He, Hui Wang, Mengruo Wang Peihao Yang Jiawei Chen Ruiting Wu Beibei Shi, Yujie Niu, Rong Zhang*. Moderate physical activity against effects of short-term PM2.5 exposure on BP via myokines-induced inflammation, Science of the Total Environment 2022, 854:158598. 18. Lina Yan, Yaxian Pang; Zhikun Wang, Haixia Luo, Yuquan Han, Shitao Ma, Lipeng Li, Jing Yuan, Yujie Niu*, Rong Zhang*. Abnormal fasting blood glucose enhances the risk of long-term exposure to air pollution on dyslipidemia: A cross-sectional study. Ecotoxicology and Environmental Safety 2022, 237:113537. 19. Xueliang Wang, Linpeng Niu, Aijuan Kang, Yaxian Pang, Yaling Zhang, Wenqing Wang, Yan Zhang, Xiaoyan Huang, Qingping Liu, Zihan Geng, Liyi He, Yujie Niu*, Rong Zhang*, Effects of ambient PM2.5 on development of psoriasiform inflammation through KRT17-dependent activation of AKT/mTOR/HIF-1α pathway. Ecotoxicology and Environmental Safety. 2022 Sep 15; 243:114008. 20. Yaling Zhang, Qingping Liu, Jie Ning, Tao Jiang, Aijuan Kang, Lipeng Li, Yaxian Pang, Boyuan Zhang, XiaoYan Huang, Qian Wang, Lei Bao, Yujie Niu, Rong Zhang*.The proteasome-dependent degradation of ALKBH5 regulates ECM deposition in PM 2.5 exposure-induced pulmonary fibrosis of mice. Journal of Hazardous Materials 2022,432:128655. 21. Huimin Sun, Yanting Li, Jianzhong Zhang, Teng Shi, Xin Li, Xue Cao, Tao Wang, Nan Kong, Yaxian Pang, Tsendmaa Bold, Yuxin Zheng, Rong Zhang*, Jinglong Tang*. Platelet Mitochondrial DNA Methylation as Epigenetic Biomarker of Short-Term Air Pollution Exposure in Healthy Subjects. Front Mol Biosci 2022 Jan 19; 8:803488. 22. Xiaoya Ji, Rui Liu, Jiajun Guo, Yanting Li, Wenting Cheng, Yaxian Pang, Yuxin Zheng, Rong Zhang*, Jinglong Tang*, Olfactory bulb microglia activation mediated neuronal death in real-ambient particulate matter exposure mice with depression-like behaviors. Science of the Total Environment 821 (2022) 153456. 23. Ziyuan Xu, Yanjian Wan, Wei Xia, Lixiao Zhou, Aizhen Wang, Lisha Shi, Yinsheng Guo, Zhenyu He, Shunqing Xu, Rong Zhang*, Fipronil and its metabolites in human seminal plasma from Shijiazhuang, north China, Chemosphere 289 (2022) 133238. 24. Aizhen Wang, Yanjian Wan, Lixiao Zhou, Wei Xia, Yinsheng Guo, Gaga Mahai, Zong Yang, Shunqing Xu, Rong Zhang*, Neonicotinoid insecticide metabolites in the seminal plasma: Associations with semen quality. Science of the Total Environment 2021.151407. 25. Zijie Pei, Jie Ning, Ning Zhang, Xu Zhang, Helin Zhang, Rong Zhang*, Genetic instability of lung induced by carbon black nanoparticles is related with Plk1 signals changes. NanoImpact 26 (2022) 100400. 26. Lipeng Li, Na Zhang, Xiaohua Wu, Tengfei Feng, Zhiming Zhao, Yaxian Pang, Yaling Zhang, Ning Wang, Jie Ning, Shibin Zhao, Tao Jiang, Baojun Shi, Yujie Niu, Rong Zhang*, Guimin Hao*, Exposure to air pollution is associated with congenital anomalies in the population born by in vitro fertilization, Environmental Research 2021.10.14. 27. Qingping Liu, Bin Han, Yaling Zhang, Tao Jiang, Jie Ning, Aijuan Kang, XiaoYan Huang, Huaxing Zhang, Yaxian Pang, Boyuan Zhang, Qian Wang, Yujie Niu, Rong Zhang*, Potential molecular mechanism of cardiac hypertrophy in mice induced by exposure to ambient PM2.5, Ecotoxicology and Environmental Safety 224 (2021) 112659. 28. Jie Ning, Yaling Zhang, Huaifang Hu, Wentao Hu, Lipeng Li, Yaxian Pang, Shitao Ma, Yujie Niu, Rong Zhang*, Association between ambient particulate matter exposure and metabolic syndrome risk: A systematic review and meta-analysis. Science of the Total Environment 782 (2021) 146855. 29. Yaxian Pang, Shipeng Liu, Lina Yan, Qian Wang, Lipeng Li, Chen Chu, Jie Ning, Boyuan Zhang, Xueliang Wang, Shitao Ma, Dong Su, Rong Zhang*, Yujie Niu*. Associations of long-term exposure to traffic-related air pollution with risk of valvular heart disease based on a cross-sectional study. Ecotoxicology and Environmental Safety 209 (2021) 111753. 30. Lixiao Zhou, Lipeng Li, Guimin Hao, Binghua Li, Sujuan Yang, Ning Wang, Jiaming Liang, Hongyue Sun, Shitao Ma, Lina Yan, Chunfang Zhao, Yanjing Wei, Yujie Niu, Rong Zhang*, Sperm mtDNA copy number, telomere length, and seminal spermatogenic cells in relation to ambient air pollution: Results of a cross-sectional study in Jing-Jin-Ji region of China. Journal of Hazardous Materials 2020.124308. 31. Bin Han, Zijie Pei, Lei Shi, Qian Wang, Chen Li, Boyuan Zhang, Xuan Su, Ning Zhang, Lixiao Zhou, Bo Zhao, Yujie Niu, Rong Zhang*, TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats, International Journal of Nanomedicine 2020:15 6279–6294. 32. Tao Wang, Haitao Wang, Jian Chen, Jiansheng Wang, Dunqiang Ren, Wei Hu, Hongmei Wang, Wei Han, Shuguang Leng, Rong Zhang*, Yuxin Zheng*. Association between air pollution and lung development in schoolchildren in China. J Epidemiol Community Health 2020; 0:1–7. 33. Lipeng Li, Lixiao Zhou, Tengfei Feng, Guimin Hao, Sujuan Yang, Ning Wang, Lina Yan, Yaxian Pang, Yujie Niu*, Rong Zhang*. Ambient air pollution exposed during preantral-antral follicle transition stage was sensitive to associate with clinical pregnancy for women receiving IVF. Environmental Pollution 265 (2020) 114973. 34. Lianhua Cui, Limei Shi, Daochuan Li, Xiaobo Li, Xuan Su, Liping Chen, Qixiao Jiang, Menghui Jiang, Jing Luo, Andong Ji, Chen Chen, Jianxun Wang, JingLong Tang, Jingbo Pi, Rui Chen, Wen Chen, Rong Zhang* and Yuxin Zheng*, Real-Ambient Particulate Matter Exposure-Induced Cardiotoxicity in C57/B6 Mice, Frontiers in Pharmacology 2020;11:199. 35. Xuan Su, Junzhi Tian, Binghua Li, Lixiao Zhou, Hui Kang, Zijie Pei, Mengyue Zhang, Chen Li, Mengqi Wu, Qian Wang, Bin Han, Chen Chu, Yaxian Pang, Jie Ning, Boyuan Zhang, Yujie Niu, Rong Zhang*. Ambient PM2.5 caused cardiac dysfunction through FoxO1-targeted cardiac hypertrophy and macrophage-activated fibrosis in mice. Chemosphere 247 (2020) 125881. 36. Lixiao Zhou, Peiyuan Li, Mengyue Zhang, Bin Han, Chen Chu, Xuan Su, Binghua Li, Hui Kang, Jie Ning, Boyuan Zhang, Shitao Ma, Dong Su, Yaxian Pang, Yujie Niu, Rong Zhang*. Carbon black nanoparticles induce pulmonary fibrosis through NLRP3 inflammasome pathway modulated by miR-96 targeted FOXO3a. Chemosphere 241 (2020) 125075. |
五、联系方式
办公电话：0311-86261272；0311-86265605
邮箱：rongzhang@hebmu.edu.cn