个人简介：

凌文华，男。中山大学教授；“国家杰青”获得者；国务院学位委员会第六、七届学科评议组成员；全国优秀教师，全国首届教材建设先进个人。长期从事营养代谢与心血管疾病究防治研究。主持国家科技部重大专项（1项）、“十一五”国家科技支撑计划（1项）、“973”课题（1项），国家自然科学基金重点项目（4项）等科研项目。已发表SCI论文280余篇，以通讯作者在Circulation、Circ Res、J Hepatol，Hepatology、Diabetes Care、Am J Clin Nutr等权威学术刊物发表研究论文。研究成果以第一完成人获“广东省科学技术奖一等奖”（1项）、“教育部自然科学一等奖”（2项）。

研究方向：

营养代谢与心血管疾病究防治研究

主要承担课题：

中老年人S-腺苷同型半胱氨酸水解酶年龄依赖性下调与血管衰老关联及其机制研究。国家自然科学金 重点项目（U22A20360），255万，2023.01-2026.12

近期发表的代表性论文：

1. Yiran You , Xu Chen , Yu Chen , Juan Pang , Qian Chen , Qiannan Liu1, Hongliang Xue, Yupeng Zeng , Jinghe Xiao , Jiaxin Mi , Yi Tang , Wenhua Ling* . Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis. Redox Biol 2023 Jul 25;65:102828. doi: 10.1016/j.redox.2023.102828. Online ahead of print.

2. Zhou Y, Zeng Y, Pan Z, Jin Y, Li Q, Pang J, Wang X, Chen Y, Yang Y, Ling W*. A Randomized Trial on Resveratrol Supplement Affecting Lipid Profile and Other Metabolic Markers in Subjects with Dyslipidemia. Nutrients. 2023;15(3).

3. Pang J, Raka F, Heirali AA, Shao W, Liu D, Gu J, Feng JN, Mineo C, Shaul PW, Qian X, Coburn B, Adeli K, Ling W*, Jin T. Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1. Nat Commun. 2023;14(1):2656.

4. You Y, Sun X, Xiao J, Chen Y, Chen X, Pang J, Mi J, Tang Y, Liu Q, Ling W*. Inhibition of S-adenosylhomocysteine hydrolase induces endothelial senescence via hTERT downregulation. Atherosclerosis. 2022;353:1-10.

5. Xue H, Chen X, Yu C, Deng Y, Zhang Y, Chen S, Chen X, Chen K, Yang Y, Ling W*. Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease. Circ Res. 2022;131(5):404-20.

6. Xiao J, You Y, Chen X, Tang Y, Chen Y, Liu Q, Liu Z, Ling W*. Higher S-adenosylhomocysteine and lower ratio of S-adenosylmethionine to S-adenosylhomocysteine were more closely associated with increased risk of subclinical atherosclerosis than homocysteine. Front Nutr. 2022;9:918698.

7. Tang Y, Chen X, Chen Q, Xiao J, Mi J, Liu Q, You Y, Chen Y, Ling W*. Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study. Nutr Metab (Lond). 2022;19(1):21.

8. Mi J, Chen X, Yiran Y, Tang Y, Liu Q, Xiao J, Ling W*. S-adenosylhomocysteine induces cellular senescence in rat aorta vascular smooth muscle cells via NF-κB-SASP pathway. J Nutr Biochem. 2022;107:109063.

9. Li Q, You Y, Zeng Y, Wang X, Pan Z, Pang J, Chen Q, Zhou Y, Jin Y, Yang Y, Ling W*. Associations between plasma tryptophan and indole-3-propionic acid levels and mortality in patients with coronary artery disease. Am J Clin Nutr. 2022;116(4):1070-7.